2009年博士畢業(yè)于中國科學院上海生物化學與細胞生物學研究所，美國加州大學洛杉磯分校（UCLA）博士后；回國后在中國科學院上海生物化學與細胞生物學研究所先后擔任助理研究員、副研究員。2018年9月入職中國科學院廣州生物醫(yī)藥與健康研究院，擔任研究員、課題組長、博士生導師。主持國家重點研發(fā)計劃項目、廣東省基礎(chǔ)與應用基礎(chǔ)研究重大項目（基石）等。為國家重點高層次青年人才、廣東省杰青、中國發(fā)育生物學專業(yè)委員會副秘書長、譜系技術(shù)與裝備研究中心執(zhí)行副主任、人類細胞譜系大科學設(shè)施副總工藝師。
“細胞學說”指出“所有生命體皆由細胞組成”，“細胞是生命的基本單元”以及“所有細胞都由此前的細胞變化而來”等核心概念，成為現(xiàn)代生物學的重要基石。然而，細胞的身份如何定義、細胞的過去現(xiàn)在和未來如何精確解碼—這些細胞的“譜系信息”在漫長的科學研究長河中，一直是科學中的重要和基本問題并沒有得到很好的解答。捕獲細胞譜系的多維信息，尤其是探究其在時間、空間維度的精確動態(tài)變化，是探索生命奧秘、解析發(fā)育程式、治愈疾病、延緩衰老的基礎(chǔ)；對細胞譜系的精準操控，是基于細胞治療、器官重建的未來再生醫(yī)學應用之不可或缺的前提。本實驗室圍繞細胞的時空動態(tài)譜系問題，主要開展以下研究：
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研究方向一：單細胞多組學與譜系示蹤技術(shù)解析細胞譜系的功能分群與異質(zhì)性
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結(jié)合單細胞多組學測序、單細胞譜系示蹤、生物信息學、人工智能以及類器官等手段重點關(guān)注發(fā)育與組織損傷中特定功能細胞的動態(tài)變化與細胞譜系決定的調(diào)控機制。
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研究方向二：原位空間多組學技術(shù)解析空間功能特異的細胞調(diào)控特征
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發(fā)展和利用高通量、高分辨率的空間多組學技術(shù)，研究組織功能實現(xiàn)的細胞基礎(chǔ)，揭示原位、動態(tài)、多維度的細胞命運決定與調(diào)控網(wǎng)絡。
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研究方向三：新型多能干細胞用于體外器官重建與功能修復
基于細胞譜系的新發(fā)現(xiàn)，實現(xiàn)譜系再造、損傷修復與器官的體外重建。
主要學術(shù)成果
聚焦細胞的時空動態(tài)譜系研究，以技術(shù)與數(shù)據(jù)驅(qū)動生物學新發(fā)現(xiàn)。開發(fā)了多種空間組學原創(chuàng)技術(shù)，繪制了小鼠著床后胚胎三個胚層建立過程高分辨率的時空動態(tài)分子圖譜，揭示了多能干細胞的發(fā)育調(diào)控網(wǎng)絡，解析了小鼠大腦的時空動態(tài)譜系發(fā)育過程，發(fā)現(xiàn)了新型的組織干細胞可用于體外器官重建與組織修復。發(fā)表研究論文及綜述七十余篇，通訊作者論文發(fā)表在《Nature》《Cell》《Nature Methods》《Nature Genetics》《Annals of the Rheumatic Disease》《Developmental?Cell》《Nature Communications》《Cell Reports》等，研究成果獲選“中國生命科學十大進展”、“2中國生物信息學十大進展”及“中國生物信息學十大應用”等。
國際干細胞學會（ISSCR）會員
中國動物學會發(fā)育生物學專業(yè)委員會副秘書長
Sanofi-SIBS 2017 Distinguished Young Faculty????
ISSCR 2017 Poster Award and Travel Award??
國家級人才項目
中國生命科學十大進展
中國生物信息學十大進展
1.?Lin L, Zhong J, Jiang F, Wang Y, Ma L, Yang J, Li Y, Gao R-R, Feng H, Cai B, Feng Z, Zhou X, Shu Y, Chen P, Wu X, Cai C-L, Wang Q, Wu G, Pei D*, Cao S*, Liu Y*, Peng G*, Chen J* & Chen Q* (2026) A single-cell time-series atlas of endothelial cell embryonic development. Cell,?S0092867426000498.
2.?Qian Y, Zhu M, Ren C, Zhou Y, Xu J, Dong L, Zhang G, Li C, Lv J, Xing Q*, Zhang G*, Peng G* & Liao N* (2026) Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer. Genomics, Proteomics & Bioinformatics, qzag001.
3.?Guo C-K, Xia C-R, Peng G*, Cao Z-J* & Gao G* (2025) Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE. Small Methods, e2401451.
4.?Meng X, Li W, Xu J, Yao Y, Gong A, Yang Y, Qu F, Guo C, Zheng H, Cui G*, Suo S* & Peng G* (2025) Spatiotemporal transcriptome atlas of developing mouse lung. Science Bulletin?70, 1641–1658.
5.?Ke J, Xu J, Liu J, Yang Y, Guo C, Xie B, Cui G, Peng G* & Suo S* (2025) High-resolution mapping of single cells in spatial context. Nat Commun?16, 6533.
6.?Yang X, Li C, He J, Xie B, Lv L, Xu J, Lin Y, Zhou C, Li M, Zeng Z, Tan J, Chen S, Cui G, Liu G*, Suo S*, Peng G* & Liang X* (2025) Spatial and single-cell transcriptomics landscape of adenomyosis. Journal of Advanced Research, S209012322501032X.
7.?Chen C, Liao Y, Zhu M, Wang L, Yu X, Li M & Peng G* (2025) Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a. Cell Reports?44, 115105.
8.?Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G*, Yan X*, Wang Y* & Zhang M* (2025) Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Advanced Science, 2413019.
9.?Jiang F, Wang H, Li Z, Cui G & Peng G* (2024) Leveraging spatial multiomics to unravel tissue architecture in embryo development. Trends in Genetics, S0168952524002713.
10.?Zou S, Peng G* & Ma Z* (2024) Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies. Nanomaterials.
11.?Wang Z, Li Z, Luan T, Cui G, Shu S, Liang Y, Zhang K, Xiao J, Yu W, Cui J, Li A*, Peng G* & Fang Y* (2024) A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2. Developmental Cell?59, 2787-2803.e8.
12.?Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Annals of the Rheumatic Diseases?83, 926–944.
13.?Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K & Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods?20, 1048–1057.
14.?Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S* & Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun?14, 4599.
15.?Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G* & Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen?12, 15.
16.?Meng X, Cui G* & Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen?12, 5.
17.?Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C* & Chen Z-J* (2022) Single-cell technologies: From research to application. The Innovation?3, 100342.
18.?Chen C, Liao Y & Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell?13, 790–807.
19.?Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N* & Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports?40, 111285.
20.?Li Z & Peng G* (2022) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports?8, 119–135.
21.?Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G* & Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation?54, e13000.
22.?Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G* & Qiao Y* (2021) Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo. Cell Proliferation?54, e13096.
23.?Peng G*, Cui G, Ke J & Jing N* (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genom Hum Genet?21, 163–181.
24.?Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H* & Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet?51, 728–738.
25.?Peng G*, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han J-DJ* & Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature?572, 528–532.
26.?Cui G, Jing N & Peng G* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo.’ Journal of Molecular Cell Biology?11, 1024–1025.
27.?Peng G* & Han J-DJ* (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res?7, 1477.
28.?Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL* & Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ?60, 463–472.
29.?Peng G* & Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci 60, 363–369.
30.?Chen J, Suo S, Tam PP, Han J-DJ*, Peng G* & Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc?12, 566–580.
完整論文情況Google?scholar: https://scholar.google.com/citations?user=s7XddBgAAAAJ
實驗室英文主頁：https://gpenglab.github.io/penglab/
