2009年博士畢業(yè)于中國(guó)科學(xué)院上海生物化學(xué)與細(xì)胞生物學(xué)研究所，美國(guó)加州大學(xué)洛杉磯分校（UCLA）博士后；回國(guó)后在中國(guó)科學(xué)院上海生物化學(xué)與細(xì)胞生物學(xué)研究所先后擔(dān)任助理研究員、副研究員。2018年9月入職中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，擔(dān)任研究員、課題組長(zhǎng)、博士生導(dǎo)師。主持國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目、廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究重大項(xiàng)目（基石）等。為國(guó)家重點(diǎn)高層次青年人才、廣東省杰青、中國(guó)發(fā)育生物學(xué)專業(yè)委員會(huì)副秘書(shū)長(zhǎng)、譜系技術(shù)與裝備研究中心執(zhí)行副主任、人類細(xì)胞譜系大科學(xué)設(shè)施副總工藝師。
“細(xì)胞學(xué)說(shuō)”指出“所有生命體皆由細(xì)胞組成”，“細(xì)胞是生命的基本單元”以及“所有細(xì)胞都由此前的細(xì)胞變化而來(lái)”等核心概念，成為現(xiàn)代生物學(xué)的重要基石。然而，細(xì)胞的身份如何定義、細(xì)胞的過(guò)去現(xiàn)在和未來(lái)如何精確解碼—這些細(xì)胞的“譜系信息”在漫長(zhǎng)的科學(xué)研究長(zhǎng)河中，一直是科學(xué)中的重要和基本問(wèn)題并沒(méi)有得到很好的解答。捕獲細(xì)胞譜系的多維信息，尤其是探究其在時(shí)間、空間維度的精確動(dòng)態(tài)變化，是探索生命奧秘、解析發(fā)育程式、治愈疾病、延緩衰老的基礎(chǔ)；對(duì)細(xì)胞譜系的精準(zhǔn)操控，是基于細(xì)胞治療、器官重建的未來(lái)再生醫(yī)學(xué)應(yīng)用之不可或缺的前提。本實(shí)驗(yàn)室圍繞細(xì)胞的時(shí)空動(dòng)態(tài)譜系問(wèn)題，主要開(kāi)展以下研究：
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研究方向一：?jiǎn)渭?xì)胞多組學(xué)與譜系示蹤技術(shù)解析細(xì)胞譜系的功能分群與異質(zhì)性
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結(jié)合單細(xì)胞多組學(xué)測(cè)序、單細(xì)胞譜系示蹤、生物信息學(xué)、人工智能以及類器官等手段重點(diǎn)關(guān)注發(fā)育與組織損傷中特定功能細(xì)胞的動(dòng)態(tài)變化與細(xì)胞譜系決定的調(diào)控機(jī)制。
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研究方向二：原位空間多組學(xué)技術(shù)解析空間功能特異的細(xì)胞調(diào)控特征
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發(fā)展和利用高通量、高分辨率的空間多組學(xué)技術(shù)，研究組織功能實(shí)現(xiàn)的細(xì)胞基礎(chǔ)，揭示原位、動(dòng)態(tài)、多維度的細(xì)胞命運(yùn)決定與調(diào)控網(wǎng)絡(luò)。
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研究方向三：新型多能干細(xì)胞用于體外器官重建與功能修復(fù)
基于細(xì)胞譜系的新發(fā)現(xiàn)，實(shí)現(xiàn)譜系再造、損傷修復(fù)與器官的體外重建。
主要學(xué)術(shù)成果
聚焦細(xì)胞的時(shí)空動(dòng)態(tài)譜系研究，以技術(shù)與數(shù)據(jù)驅(qū)動(dòng)生物學(xué)新發(fā)現(xiàn)。開(kāi)發(fā)了多種空間組學(xué)原創(chuàng)技術(shù)，繪制了小鼠著床后胚胎三個(gè)胚層建立過(guò)程高分辨率的時(shí)空動(dòng)態(tài)分子圖譜，揭示了多能干細(xì)胞的發(fā)育調(diào)控網(wǎng)絡(luò)，解析了小鼠大腦的時(shí)空動(dòng)態(tài)譜系發(fā)育過(guò)程，發(fā)現(xiàn)了新型的組織干細(xì)胞可用于體外器官重建與組織修復(fù)。發(fā)表研究論文及綜述七十余篇，通訊作者論文發(fā)表在《Nature》《Cell》《Nature Methods》《Nature Genetics》《Annals of the Rheumatic Disease》《Developmental?Cell》《Nature Communications》《Cell Reports》等，研究成果獲選“中國(guó)生命科學(xué)十大進(jìn)展”、“2中國(guó)生物信息學(xué)十大進(jìn)展”及“中國(guó)生物信息學(xué)十大應(yīng)用”等。
國(guó)際干細(xì)胞學(xué)會(huì)（ISSCR）會(huì)員
中國(guó)動(dòng)物學(xué)會(huì)發(fā)育生物學(xué)專業(yè)委員會(huì)副秘書(shū)長(zhǎng)
Sanofi-SIBS 2017 Distinguished Young Faculty????
ISSCR 2017 Poster Award and Travel Award??
國(guó)家級(jí)人才項(xiàng)目
中國(guó)生命科學(xué)十大進(jìn)展
中國(guó)生物信息學(xué)十大進(jìn)展
1.?Lin L, Zhong J, Jiang F, Wang Y, Ma L, Yang J, Li Y, Gao R-R, Feng H, Cai B, Feng Z, Zhou X, Shu Y, Chen P, Wu X, Cai C-L, Wang Q, Wu G, Pei D*, Cao S*, Liu Y*, Peng G*, Chen J* & Chen Q* (2026) A single-cell time-series atlas of endothelial cell embryonic development. Cell,?S0092867426000498.
2.?Qian Y, Zhu M, Ren C, Zhou Y, Xu J, Dong L, Zhang G, Li C, Lv J, Xing Q*, Zhang G*, Peng G* & Liao N* (2026) Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer. Genomics, Proteomics & Bioinformatics, qzag001.
3.?Guo C-K, Xia C-R, Peng G*, Cao Z-J* & Gao G* (2025) Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE. Small Methods, e2401451.
4.?Meng X, Li W, Xu J, Yao Y, Gong A, Yang Y, Qu F, Guo C, Zheng H, Cui G*, Suo S* & Peng G* (2025) Spatiotemporal transcriptome atlas of developing mouse lung. Science Bulletin?70, 1641–1658.
5.?Ke J, Xu J, Liu J, Yang Y, Guo C, Xie B, Cui G, Peng G* & Suo S* (2025) High-resolution mapping of single cells in spatial context. Nat Commun?16, 6533.
6.?Yang X, Li C, He J, Xie B, Lv L, Xu J, Lin Y, Zhou C, Li M, Zeng Z, Tan J, Chen S, Cui G, Liu G*, Suo S*, Peng G* & Liang X* (2025) Spatial and single-cell transcriptomics landscape of adenomyosis. Journal of Advanced Research, S209012322501032X.
7.?Chen C, Liao Y, Zhu M, Wang L, Yu X, Li M & Peng G* (2025) Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a. Cell Reports?44, 115105.
8.?Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G*, Yan X*, Wang Y* & Zhang M* (2025) Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Advanced Science, 2413019.
9.?Jiang F, Wang H, Li Z, Cui G & Peng G* (2024) Leveraging spatial multiomics to unravel tissue architecture in embryo development. Trends in Genetics, S0168952524002713.
10.?Zou S, Peng G* & Ma Z* (2024) Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies. Nanomaterials.
11.?Wang Z, Li Z, Luan T, Cui G, Shu S, Liang Y, Zhang K, Xiao J, Yu W, Cui J, Li A*, Peng G* & Fang Y* (2024) A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2. Developmental Cell?59, 2787-2803.e8.
12.?Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Annals of the Rheumatic Diseases?83, 926–944.
13.?Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K & Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods?20, 1048–1057.
14.?Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S* & Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun?14, 4599.
15.?Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G* & Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen?12, 15.
16.?Meng X, Cui G* & Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen?12, 5.
17.?Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C* & Chen Z-J* (2022) Single-cell technologies: From research to application. The Innovation?3, 100342.
18.?Chen C, Liao Y & Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell?13, 790–807.
19.?Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N* & Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports?40, 111285.
20.?Li Z & Peng G* (2022) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports?8, 119–135.
21.?Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G* & Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation?54, e13000.
22.?Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G* & Qiao Y* (2021) Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo. Cell Proliferation?54, e13096.
23.?Peng G*, Cui G, Ke J & Jing N* (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genom Hum Genet?21, 163–181.
24.?Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H* & Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet?51, 728–738.
25.?Peng G*, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han J-DJ* & Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature?572, 528–532.
26.?Cui G, Jing N & Peng G* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo.’ Journal of Molecular Cell Biology?11, 1024–1025.
27.?Peng G* & Han J-DJ* (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res?7, 1477.
28.?Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL* & Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ?60, 463–472.
29.?Peng G* & Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci 60, 363–369.
30.?Chen J, Suo S, Tam PP, Han J-DJ*, Peng G* & Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc?12, 566–580.
完整論文情況Google?scholar: https://scholar.google.com/citations?user=s7XddBgAAAAJ
實(shí)驗(yàn)室英文主頁(yè)：https://gpenglab.github.io/penglab/
